Matthijs Constantijn Dorst
Neuroscience PhD student in the Silberberg lab
at the Karolinska Institutet in Stockholm, Sweden.
Biker, geek, excessive zip-tie user.
Basal ganglionist and patch-clamp electrophysiologist for my sins.
In my research I combine multi-cell ex vivo
patch clamp electrophysiology with
chemogenetics, optogenetics and pharmacological manipulation to investigate the
neural microcircuits of the Striatum. Through my background in machine learning and
experience in experimental neuroscience I aim to unravel the complex web of interactions
between acetylcholine and dopamine.
2020. The microcircuits of striatum in silico. Under review
Targeting VGLUT2 in mature dopamine neurons decreases mesoaccumbal glutamatergic transmission and identifies a role for
glutamate co-release in synaptic plasticity by increasing baseline AMPA/NMDA ratio.
Frontiers in neural circuits, 12, p.64.
2018. Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales—Simulations of Direct Pathway MSNs Investigate
the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4. 2. Frontiers in neural circuits, 12, p.3.
2016. Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons.
Elife, 5, p.e16088.
Disynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Last updated: 2020-01-25.