To describe the clinical presentation of presumptive acute post-hypoxic myoclonus in a cat and a dog after cardiopulmonary arrest (CPA). In people, acute post-hypoxic myoclonus is a transient focal, multifocal, or generalized rhythmic myoclonus that results from global hypoxic-ischemic brain injury and may be cortical or subcortical in origin, specifically brainstem-generated. Post-hypoxic myoclonus typically presents within 48 h of CPA while the patient is still comatose. Although this neurologic sign has historically been associated with a poorer prognosis, recent studies suggest that evaluation of its clinical characterization in conjunction with electroencephalographic features should be considered.