PELP1 expression is associated with disease progression in inflammation-driven oral cancer.

Venkatraman, Ganesh; Somashankar, Vedhashree; Saravanan, Roshni; Mathavan, Anugraha; Seetharaman, Abirami; Khodabux, Rachael Jahander; Chelvan, Harikrishnan Thamizh; Rayala, Suresh Kumar

doi:10.1007/s12094-026-04537-9

PELP1 expression is associated with disease progression in inflammation-driven oral cancer.

2026-08-16, Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (10.1007/s12094-026-04537-9) (online)
Ganesh Venkatraman, Vedhashree Somashankar, Roshni Saravanan, Anugraha Mathavan, Abirami Seetharaman, Rachael Jahander Khodabux, Harikrishnan Thamizh Chelvan, and Suresh Kumar Rayala (?)

Chronic inflammation is an important contributor to the development of oral cancer, particularly in Oral Potentially Malignant Disorders (OPMDs) progressing to Oral Squamous Cell Carcinoma (OSCC). PELP1 is an inflammation-responsive nuclear coregulator identified in multiple cancers; however, its role in oral cancer remains unclear. This study evaluates the expression of PELP1 and determines its clinical significance in inflammation-associated oral tumorigenesis.

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PELP1 expression is associated with disease progression in inflammation-driven oral cancer.